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The researchers highlighted silymarin's liver-protective effects in cases of drug-induced liver injury, fatty liver disease (both alcoholic and nonalcoholic), and alcoholic cirrhosis, attributing successes to the compound's ability to prevent cytotoxicity by reducing oxidative stress on the liver.3 Many of the studies covered in the review administered 420mg of silymarin per day

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However, some of the changes of the antioxidant genes in the aged mice are inconsistent, and the phenotype might be tissue specific

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